A new class of Ru(ii) polyazine agents with potential for photodynamic therapy†
Abstract
Appending anthracene units to [(bpy)2Ru(dpp)]2+ results in Ru(II) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)]2+ and [(Anthbpy)2Ru(dpp)]2+ are the first metal–organic Ru(II) agent with dpp ligands shown to photomodify DNA in the presence or absence of oxygen, while also binding protein in an oxygen-dependent manner.