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Issue 6, 2016
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Chemo-enzymatic Baeyer–Villiger oxidation of 4-methylcyclohexanone via kinetic resolution of racemic carboxylic acids: direct access to enantioenriched lactone

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Abstract

A new method for the asymmetric chemo-enzymatic Baeyer–Villiger oxidation of prochiral 4-methylcyclohexanone to (R)-4-methylcaprolactone in the presence of (±)-4-methyloctanoic acid, Candida Antarctica lipase B and 30% aq. H2O2 has been developed. A mechanism for the asymmetric induction based on kinetic resolution of racemic carboxylic acids is proposed.

Graphical abstract: Chemo-enzymatic Baeyer–Villiger oxidation of 4-methylcyclohexanone via kinetic resolution of racemic carboxylic acids: direct access to enantioenriched lactone

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Publication details

The article was received on 13 Oct 2015, accepted on 16 Nov 2015 and first published on 18 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC08519E
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Citation: Chem. Commun., 2016,52, 1230-1233

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    Chemo-enzymatic Baeyer–Villiger oxidation of 4-methylcyclohexanone via kinetic resolution of racemic carboxylic acids: direct access to enantioenriched lactone

    A. Drożdż and A. Chrobok, Chem. Commun., 2016, 52, 1230
    DOI: 10.1039/C5CC08519E

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