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Issue 7, 2016
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Enantioselective targeting left-handed Z-G-quadruplex

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Abstract

Herein, we report the first example where an M-enantiomer of a chiral metal complex can selectively stabilize a left-handed G-quadruplex, but its P-enantiomer cannot. The interactions between the chiral metal complexes and the left-handed G-quadruplex were evaluated by UV melting, circular dichroism, isothermal titration calorimetry, gel electrophoresis and NMR titrations.

Graphical abstract: Enantioselective targeting left-handed Z-G-quadruplex

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Publication details

The article was received on 09 Oct 2015, accepted on 16 Nov 2015 and first published on 16 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC08401F
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Chem. Commun., 2016,52, 1365-1368

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    Enantioselective targeting left-handed Z-G-quadruplex

    A. Zhao, C. Zhao, J. Ren and X. Qu, Chem. Commun., 2016, 52, 1365
    DOI: 10.1039/C5CC08401F

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