Issue 7, 2016

Enantioselective targeting left-handed Z-G-quadruplex

Abstract

Herein, we report the first example where an M-enantiomer of a chiral metal complex can selectively stabilize a left-handed G-quadruplex, but its P-enantiomer cannot. The interactions between the chiral metal complexes and the left-handed G-quadruplex were evaluated by UV melting, circular dichroism, isothermal titration calorimetry, gel electrophoresis and NMR titrations.

Graphical abstract: Enantioselective targeting left-handed Z-G-quadruplex

Supplementary files

Article information

Article type
Communication
Submitted
09 Oct 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

Chem. Commun., 2016,52, 1365-1368

Author version available

Enantioselective targeting left-handed Z-G-quadruplex

A. Zhao, C. Zhao, J. Ren and X. Qu, Chem. Commun., 2016, 52, 1365 DOI: 10.1039/C5CC08401F

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