Pd-catalyzed gem-difluoroallylation of arylboronic acids with γ,γ-difluoroallylic acetates

Abstract

A highly regio- and stereo-selective palladium-catalyzed gem-difluoroallylation of arylboronic acids with γ,γ-difluoroallylic acetates has been described. The method allows the synthesis of a variety of gem-difluoroallylated arenes with a tosyloxy group on the CC double bond, thus providing a good opportunity for down-stream transformations.