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Issue 11, 2016
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The crystal structure of a 2′,4′-BNANC[N–Me]-modified antisense gapmer in complex with the target RNA

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Abstract

It has been confirmed by our previous studies that a 2′,4′-BNANC[N–Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties.

Graphical abstract: The crystal structure of a 2′,4′-BNANC[N–Me]-modified antisense gapmer in complex with the target RNA

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Publication details

The article was received on 06 Oct 2015, accepted on 21 Dec 2015 and first published on 21 Dec 2015


Article type: Communication
DOI: 10.1039/C5CC08300A
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Citation: Chem. Commun., 2016,52, 2354-2357
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    The crystal structure of a 2′,4′-BNANC[N–Me]-modified antisense gapmer in complex with the target RNA

    J. Kondo, Y. Nomura, Y. Kitahara, S. Obika and H. Torigoe, Chem. Commun., 2016, 52, 2354
    DOI: 10.1039/C5CC08300A

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