Direct C–H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis

Neeraj Kumar Mishra; Miji Choi; Hyeim Jo; Yongguk Oh; Satyasheel Sharma; Sang Hoon Han; Taejoo Jeong; Sangil Han; Seok-Yong Lee; In Su Kim

doi:10.1039/C5CC07767B

Direct C–H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis†

Neeraj Kumar Mishra,^a Miji Choi,^a Hyeim Jo,^a Yongguk Oh,^a Satyasheel Sharma,^a Sang Hoon Han,^a Taejoo Jeong,^a Sangil Han,^a Seok-Yong Lee^a and In Su Kim*^a

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^a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

Abstract

The rhodium(III)-catalyzed direct functionalization of aniline C–H bonds with α-diazo compounds is described. These transformations provide a facile construction of ortho-alkylated anilines with diazo malonates or highly substituted indoles with diazo acetoacetates.

Chemical Communications

Direct C–H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis†

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Direct C–H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis

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