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Issue 99, 2015
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A KISS (keep it simple, sensor) array for glycosaminoglycans

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Abstract

Herein, we demonstrate that it is possible to design a sensor array with one multivalent cationic receptor (a dendrigraft of lysine) and one fluorescent anionic indicator (a fluorescein-labeled peptide). Depending on the loading of the indicator on the receptor, negatively charged glycosaminoglycans (GAGs) induce a positive or negative variation of the fluorescent signal as they displace the indicators from the receptor or they compact the indicators on the receptor's surface, respectively. This unique strategy allows not only the blind identification of pure GAGs with a level of accuracy of 100%, but also the differentiation of mixtures.

Graphical abstract: A KISS (keep it simple, sensor) array for glycosaminoglycans

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Publication details

The article was received on 11 Sep 2015, accepted on 13 Oct 2015 and first published on 13 Oct 2015


Article type: Communication
DOI: 10.1039/C5CC07628E
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Citation: Chem. Commun., 2015,51, 17544-17547
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    A KISS (keep it simple, sensor) array for glycosaminoglycans

    J. Francoia and L. Vial, Chem. Commun., 2015, 51, 17544
    DOI: 10.1039/C5CC07628E

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