Issue 93, 2015

Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

Abstract

The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.

Graphical abstract: Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
02 Sep 2015
Accepted
17 Sep 2015
First published
17 Sep 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 16605-16608

Author version available

Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

S. Yano, M. Naemura, A. Toshimitsu, M. Akiyama, A. Ikeda, J. Kikuchi, X. Shen, Q. Duan, A. Narumi, M. Inoue, K. Ohkubo and S. Fukuzumi, Chem. Commun., 2015, 51, 16605 DOI: 10.1039/C5CC07353G

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