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Issue 96, 2015
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In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

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Abstract

In vivo fluorescence imaging of β-amyloid (Aβ) plaques in the brain is expected to be used as a new method for detecting Alzheimer's disease (AD). We synthesized novel push–pull dimethylaminothiophenyl (DTM) derivatives and evaluated their utility as in vivo fluorescence imaging probes targeting Aβ plaques. As a result, we found that DTM-2 is a promising fluorescent probe for Aβ plaques in the AD brains.

Graphical abstract: In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

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Publication details

The article was received on 07 Aug 2015, accepted on 28 Sep 2015 and first published on 12 Oct 2015


Article type: Communication
DOI: 10.1039/C5CC06628J
Chem. Commun., 2015,51, 17124-17127

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    In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

    H. Watanabe, M. Ono and H. Saji, Chem. Commun., 2015, 51, 17124
    DOI: 10.1039/C5CC06628J

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