Rh(iii)-catalyzed chelation-assisted intermolecular carbenoid functionalization of α-imino Csp3–H bonds†
Abstract
A Rh(III)-catalyzed cross-coupling/cyclization cascade of α-imino Csp3–H bonds with donor/acceptor α-acyl diazocarbonyl compounds has been developed. This novel transformation involves ligand-directed Csp3–H bond functionalization with carbenoids under the pyridine-chelation assistance, and offered an efficient access to synthetically versatile polysubstituted N-(2-pyridyl)pyrroles with a broad range of functional group tolerance.