Issue 80, 2015

Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death

Abstract

Triphenylamines are on/off fluorescent DNA minor groove binders, allowing nuclear staining of fixed cells. By contrast, they accumulate in the cytoplasm of living cells and efficiently trigger cell apoptosis upon prolonged visible light irradiation. This process occurs concomitantly with their subcellular re-localization to the nucleus, enabling fluorescence imaging of apoptosis.

Graphical abstract: Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death

Supplementary files

Article information

Article type
Communication
Submitted
17 Jul 2015
Accepted
12 Aug 2015
First published
17 Aug 2015

Chem. Commun., 2015,51, 14881-14884

Author version available

Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death

R. Chennoufi, H. Bougherara, N. Gagey-Eilstein, B. Dumat, E. Henry, F. Subra, F. Mahuteau-Betzer, P. Tauc, M.-P. Teulade-Fichou and E. Deprez, Chem. Commun., 2015, 51, 14881 DOI: 10.1039/C5CC05970D

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