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Issue 70, 2015
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Efficient heterocyclisation by (di)terpene synthases

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While cyclic ether forming terpene synthases are known, the basis for such heterocyclisation is unclear. Here it is reported that numerous (di)terpene synthases, particularly including the ancestral ent-kaurene synthase, efficiently produce isomers of manoyl oxide from the stereochemically appropriate substrate. Accordingly, such heterocyclisation is easily accomplished by terpene synthases. Indeed, the use of single residue changes to induce production of the appropriate substrate in the upstream active site leads to efficient bifunctional enzymes producing isomers of manoyl oxide, representing novel enzymatic activity.

Graphical abstract: Efficient heterocyclisation by (di)terpene synthases

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The article was received on 11 Jul 2015, accepted on 21 Jul 2015 and first published on 21 Jul 2015

Article type: Communication
DOI: 10.1039/C5CC05754J
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Chem. Commun., 2015,51, 13485-13487

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    Efficient heterocyclisation by (di)terpene synthases

    S. Mafu, K. C. Potter, M. L. Hillwig, S. Schulte, J. Criswell and R. J. Peters, Chem. Commun., 2015, 51, 13485
    DOI: 10.1039/C5CC05754J

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