Synthetic tools for studying the chemical biology of InsP8

Andrew M. Riley; Huanchen Wang; Stephen B. Shears; Barry V. L. Potter

doi:10.1039/C5CC05017K

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Synthetic tools for studying the chemical biology of InsP₈†

Andrew M. Riley,^a Huanchen Wang,^b Stephen B. Shears^b and Barry V. L. Potter*^ac

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* Corresponding authors

^a Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK

^b Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

^c Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
E-mail: barry.potter@pharm.ox.ac.uk
Fax: +44-1865-271853
Tel: +44-1865-271945

Abstract

To synthesise stabilised mimics of InsP₈, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP₈ metabolism.

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Article information

DOI: https://doi.org/10.1039/C5CC05017K
Article type: Communication
Submitted: 18 Jun 2015
Accepted: 03 Jul 2015
First published: 03 Jul 2015
This article is Open Access

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Chem. Commun., 2015,51, 12605-12608

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Synthetic tools for studying the chemical biology of InsP₈

A. M. Riley, H. Wang, S. B. Shears and B. V. L. Potter, Chem. Commun., 2015, 51, 12605 DOI: 10.1039/C5CC05017K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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