Issue 62, 2015

Supramolecular chirality in self-assembled peptide amphiphile nanostructures

Abstract

Induced supramolecular chirality was investigated in the self-assembled peptide amphiphile (PA) nanosystems. Having shown that peptide chirality can be transferred to the covalently-attached achiral pyrene moiety upon PA self-assembly, the chiral information is transferred to molecular pyrene via weak noncovalent interactions. In the first design of a supramolecular chiral system, the chromophore was covalently attached to a peptide sequence (VVAGH) via an ε-aminohexanoic acid spacer. Covalent attachment yielded a PA molecule self-assembling into nanofibers. In the second design, the chromophore was encapsulated within the hydrophobic core of self-assembled nanofibers of another PA consisting of the same peptide sequence attached to lauric acid. We observed that supramolecular chirality was induced in the chromophore by PA assembly into chiral nanostructures, whether it was covalently attached, or noncovalently bound.

Graphical abstract: Supramolecular chirality in self-assembled peptide amphiphile nanostructures

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2015
Accepted
29 Jun 2015
First published
30 Jun 2015

Chem. Commun., 2015,51, 12470-12473

Author version available

Supramolecular chirality in self-assembled peptide amphiphile nanostructures

R. Garifullin and M. O. Guler, Chem. Commun., 2015, 51, 12470 DOI: 10.1039/C5CC04982B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements