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Issue 66, 2015
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Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

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Abstract

The enantioselective preparation of pharmacologically interesting chroman-fused spirooxindole derivatives is described based on an organocatalytic multicomponent cascade reaction. The compounds synthesized using this method potently inhibited the proliferation of various cancer cell lines. The most potent compound (7e) induced caspase-independent apoptosis and cell cycle arrest in MCF-7 breast cancer cells by interfering with the p53–MDM2 interaction and downstream pathways.

Graphical abstract: Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

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Publication details

The article was received on 16 Jun 2015, accepted on 02 Jul 2015 and first published on 02 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC04968G
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Chem. Commun., 2015,51, 13113-13116

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    Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

    R. Zhou, Q. Wu, M. Guo, W. Huang, X. He, L. Yang, F. Peng, G. He and B. Han, Chem. Commun., 2015, 51, 13113
    DOI: 10.1039/C5CC04968G

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