Issue 66, 2015

Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

Abstract

The enantioselective preparation of pharmacologically interesting chroman-fused spirooxindole derivatives is described based on an organocatalytic multicomponent cascade reaction. The compounds synthesized using this method potently inhibited the proliferation of various cancer cell lines. The most potent compound (7e) induced caspase-independent apoptosis and cell cycle arrest in MCF-7 breast cancer cells by interfering with the p53–MDM2 interaction and downstream pathways.

Graphical abstract: Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2015
Accepted
02 Jul 2015
First published
02 Jul 2015

Chem. Commun., 2015,51, 13113-13116

Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation

R. Zhou, Q. Wu, M. Guo, W. Huang, X. He, L. Yang, F. Peng, G. He and B. Han, Chem. Commun., 2015, 51, 13113 DOI: 10.1039/C5CC04968G

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