Issue 78, 2015
From the journal:

Chemical Communications

Total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease†

Yun-Kun Qi,‡ab   Hao-Nan Chang,‡ab   Kai-Mai Pan,b   Chang-Lin Tianac  and  Ji-Shen Zheng*a  

* Corresponding authors

a High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, China
E-mail: jszheng@hmfl.cas.cn

b Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing 100084, China

c School of Life Sciences, University of Science and Technology of China, Hefei 230026, China

Abstract

The first total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease is described by native chemical ligation. Chemical synthesis of azide-labeled proteins would provide useful protein tools for biochemical, biophysical or medical studies.

Graphical abstract: Total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease

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Article information

DOI
https://doi.org/10.1039/C5CC04846J
Article type
Communication
Submitted
11 Jun 2015
Accepted
03 Aug 2015
First published
03 Aug 2015

Chem. Commun., 2015,51, 14632-14635

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Total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease

Y. Qi, H. Chang, K. Pan, C. Tian and J. Zheng, Chem. Commun., 2015, 51, 14632 DOI: 10.1039/C5CC04846J

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