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Issue 66, 2015
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Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2

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Abstract

A versatile method has been found to catalyze the dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using Pd/C, volatile iPr3SiH and CO2 gas without the liberation of any salts. A simple filtration/evaporation process facilitates the easy isolation of the product, thereby enhancing the utility of Tsoc as an amine-protecting group in organic synthesis.

Graphical abstract: Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2

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Publication details

The article was received on 04 Jun 2015, accepted on 30 Jun 2015 and first published on 17 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC04594K
Chem. Commun., 2015,51, 13110-13112

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    Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2

    S. Tanaka, T. Yamamura, S. Nakane and M. Kitamura, Chem. Commun., 2015, 51, 13110
    DOI: 10.1039/C5CC04594K

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