Issue 69, 2015
From the journal:

Chemical Communications

Engineering polypeptide folding through trans double bonds: transformation of miniature β-meanders to hybrid helices†

Mothukuri Ganesh Kumar,a   Sushil N. Benke,a   K. Muruga Poopathi Raja*b  and  Hosahudya N. Gopi*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, India
E-mail: hn.gopi@iiserpune.ac.in

b Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, India
E-mail: murugapoopathiraja@gmail.com

Abstract

Utilization of conjugated double bonds to engineer the novel folded miniature β-meander type structures, single step transformation of miniature β-meanders into ααγ4-hybrid peptide 10/12-helices using catalytic hydrogenation, their solution and single crystal conformations are reported.

Graphical abstract: Engineering polypeptide folding through trans double bonds: transformation of miniature β-meanders to hybrid helices

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Article information

DOI
https://doi.org/10.1039/C5CC04523A
Article type
Communication
Submitted
02 Jun 2015
Accepted
15 Jul 2015
First published
15 Jul 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 13397-13399

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Engineering polypeptide folding through trans double bonds: transformation of miniature β-meanders to hybrid helices

M. Ganesh Kumar, S. N. Benke, K. M. Poopathi Raja and H. N. Gopi, Chem. Commun., 2015, 51, 13397 DOI: 10.1039/C5CC04523A

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