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Issue 44, 2015
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An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

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Abstract

A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells.

Graphical abstract: An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

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Supplementary files

Article information


Submitted
16 Apr 2015
Accepted
23 Apr 2015
First published
28 Apr 2015

This article is Open Access

Chem. Commun., 2015,51, 9169-9172
Article type
Communication
Author version available

An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

A. Gandioso, E. Shaili, A. Massaguer, G. Artigas, A. González-Cantó, J. A. Woods, P. J. Sadler and V. Marchán, Chem. Commun., 2015, 51, 9169
DOI: 10.1039/C5CC03180J

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