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Issue 54, 2015
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A porphyrin photosensitized metal–organic framework for cancer cell apoptosis and caspase responsive theranostics

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Abstract

A photosensitized and caspase-responsive multifunctional nanoprobe was designed by assembling a porphyrin, a folate targeting-motif and a dye-labelled peptide in a metal–organic framework (MOF) cage, which significantly increases the singlet oxygen quantum yield of porphyrin by 6.2 times, and achieves high efficient cancer therapy and in situ therapeutic monitoring with caspase-3 activation. The integration of theranostic functions in a single nanocarrier holds great promise in precision cancer diagnosis and treatment.

Graphical abstract: A porphyrin photosensitized metal–organic framework for cancer cell apoptosis and caspase responsive theranostics

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Publication details

The article was received on 12 Apr 2015, accepted on 20 May 2015 and first published on 20 May 2015


Article type: Communication
DOI: 10.1039/C5CC03028E
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Citation: Chem. Commun., 2015,51, 10831-10834

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    A porphyrin photosensitized metal–organic framework for cancer cell apoptosis and caspase responsive theranostics

    L. Zhang, J. Lei, F. Ma, P. Ling, J. Liu and H. Ju, Chem. Commun., 2015, 51, 10831
    DOI: 10.1039/C5CC03028E

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