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Issue 48, 2015
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Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery

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Abstract

A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.

Graphical abstract: Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery

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Publication details

The article was received on 08 Apr 2015, accepted on 14 May 2015 and first published on 14 May 2015


Article type: Communication
DOI: 10.1039/C5CC02907D
Chem. Commun., 2015,51, 9833-9836
  • Open access: Creative Commons BY license
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    Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery

    J. Zhou, N. Hao, T. De Zoyza, M. Yan and O. Ramström, Chem. Commun., 2015, 51, 9833
    DOI: 10.1039/C5CC02907D

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