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Issue 75, 2015
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Mimicking the active site of aldehyde dehydrogenases: stabilization of carbonyl hydrates through hydrogen bonds

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Abstract

Aldehyde hydrates are important but highly unstable, transient intermediates in biological and synthetic oxidations to carboxylic acids. We here report N-oxides as the first class of chemical reagents capable of stabilizing such water adducts. This stabilizing effect (studied in solution and in the solid state) seems to be based on the formation of hydrogen bonds.

Graphical abstract: Mimicking the active site of aldehyde dehydrogenases: stabilization of carbonyl hydrates through hydrogen bonds

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Article information


Submitted
05 Apr 2015
Accepted
09 Jun 2015
First published
09 Jun 2015

Chem. Commun., 2015,51, 14175-14178
Article type
Communication

Mimicking the active site of aldehyde dehydrogenases: stabilization of carbonyl hydrates through hydrogen bonds

A. J. K. Roth, M. Tretbar and C. B. W. Stark, Chem. Commun., 2015, 51, 14175
DOI: 10.1039/C5CC02831K

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