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Issue 49, 2015
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Regioselective direct oxidative C–H cyanation of quinoline and its derivatives catalyzed by vanadium-containing heteropoly acids

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Abstract

A direct oxidative C–H cyanation of quinoline and its derivatives using trimethylsilyl cyanide as the cyano source and molecular oxygen as the terminal oxidant has been developed. In the presence of catalytic amounts of vanadium-containing heteropoly acids, e.g., H7PV4Mo8O40, cyanation of various quinoline and its derivatives preferentially took place at the 4-position, affording the corresponding substituted 4-cyanoquinolines as the major products.

Graphical abstract: Regioselective direct oxidative C–H cyanation of quinoline and its derivatives catalyzed by vanadium-containing heteropoly acids

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Article information


Submitted
03 Apr 2015
Accepted
13 May 2015
First published
18 May 2015

Chem. Commun., 2015,51, 10034-10037
Article type
Communication
Author version available

Regioselective direct oxidative C–H cyanation of quinoline and its derivatives catalyzed by vanadium-containing heteropoly acids

K. Yamaguchi, N. Xu, X. Jin, K. Suzuki and N. Mizuno, Chem. Commun., 2015, 51, 10034
DOI: 10.1039/C5CC02797G

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