Issue 66, 2015

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

Abstract

The as-yet unidentified E. coli metabolite colibactin induces DNA damage in eukaryotic cells and promotes tumorigenesis. Its wide distribution in pathogenic and probiotic strains has raised great interest in its structure and biosynthesis. Here we show that colibactin formation involves a rare aminomalonyl unit used as a building block.

Graphical abstract: Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

Supplementary files

Article information

Article type
Communication
Submitted
01 Apr 2015
Accepted
07 Jul 2015
First published
08 Jul 2015

Chem. Commun., 2015,51, 13138-13141

Author version available

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

A. O. Brachmann, C. Garcie, V. Wu, P. Martin, R. Ueoka, E. Oswald and J. Piel, Chem. Commun., 2015, 51, 13138 DOI: 10.1039/C5CC02718G

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