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Issue 43, 2015
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Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

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Abstract

An isothiocyanate-functionalized tetraphenylethene is synthesized and used as a fluorescent bioprobe for mitochondrion imaging with high specificity and photostability. The covalent conjugation of the bioprobe to mitochondrial proteins endows it with high resistance to microenvironmental changes, enabling it for real-time monitoring of mitophagy.

Graphical abstract: Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

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Publication details

The article was received on 25 Mar 2015, accepted on 23 Apr 2015 and first published on 23 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC02486B
Citation: Chem. Commun., 2015,51, 9022-9025

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    Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

    W. Zhang, R. T. K. Kwok, Y. Chen, S. Chen, E. Zhao, C. Y. Y. Yu, J. W. Y. Lam, Q. Zheng and B. Z. Tang, Chem. Commun., 2015, 51, 9022
    DOI: 10.1039/C5CC02486B

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