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Issue 47, 2015
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Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation

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Abstract

We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine–hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.

Graphical abstract: Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation

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Publication details

The article was received on 21 Mar 2015, accepted on 07 May 2015 and first published on 11 May 2015


Article type: Communication
DOI: 10.1039/C5CC02367J
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Citation: Chem. Commun., 2015,51, 9662-9665

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    Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation

    X. Zhang, P. Sun, L. Huangshan, B. Hu and P. B. Messersmith, Chem. Commun., 2015, 51, 9662
    DOI: 10.1039/C5CC02367J

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