Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

Jian-Yuan Huang; Yongsheng Gao; Lara Cutlar; Jonathan O'Keeffe-Ahern; Tianyu Zhao; Feng-Huei Lin; Dezhong Zhou; Sean McMahon; Udo Greiser; Wei Wang; Wenxin Wang

doi:10.1039/C5CC02193F

Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy†

Jian-Yuan Huang,^ab Yongsheng Gao,^a Lara Cutlar,^a Jonathan O'Keeffe-Ahern,^a Tianyu Zhao,^a Feng-Huei Lin,^bc Dezhong Zhou,*^a Sean McMahon,^a Udo Greiser,^a Wei Wang^ad and Wenxin Wang*^ad

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* Corresponding authors

^a Charles Institute of Dermatology, University College Dublin, Dublin 4, Ireland
E-mail: dezhong.zhou@ucd.ie, wenxin.wang@ucd.ie

^b Institute of Biomedical Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Rd., Taipei 100, Taiwan

^c Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Miaoli County, Taiwan

^d School of Materials Science and Engineering, Tianjin University, Tianjin, China

Abstract

Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.

Chemical Communications

Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy†

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Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

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