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Issue 46, 2015
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A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

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Abstract

A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.

Graphical abstract: A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

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Publication details

The article was received on 13 Mar 2015, accepted on 01 May 2015 and first published on 04 May 2015


Article type: Communication
DOI: 10.1039/C5CC02149A
Chem. Commun., 2015,51, 9567-9570

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    A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

    P. Liu, J. Xu, D. Yan, P. Zhang, F. Zeng, B. Li and S. Wu, Chem. Commun., 2015, 51, 9567
    DOI: 10.1039/C5CC02149A

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