Jump to main content
Jump to site search

Issue 46, 2015
Previous Article Next Article

A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

Author affiliations

Abstract

A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.

Graphical abstract: A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Mar 2015, accepted on 01 May 2015 and first published on 04 May 2015


Article type: Communication
DOI: 10.1039/C5CC02149A
Citation: Chem. Commun., 2015,51, 9567-9570
  •   Request permissions

    A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

    P. Liu, J. Xu, D. Yan, P. Zhang, F. Zeng, B. Li and S. Wu, Chem. Commun., 2015, 51, 9567
    DOI: 10.1039/C5CC02149A

Search articles by author

Spotlight

Advertisements