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Issue 42, 2015
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A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes

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Abstract

Various 3,5-disubstituted-1,2,4-oxadiazoles are smoothly formed via copper-catalyzed cascade annulation of amidines and methylarenes. This tandem oxidation–amination–cyclization transformation represents a straightforward protocol to prepare 1,2,4-oxadiazoles from easily available starting materials, with inexpensive copper catalysts and green oxidants. It has the advantages of atom- and step-economy, good functional group tolerance, as well as operational simplicity.

Graphical abstract: A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes

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Article information


Submitted
12 Mar 2015
Accepted
14 Apr 2015
First published
14 Apr 2015

Chem. Commun., 2015,51, 8857-8860
Article type
Communication
Author version available

A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes

W. Guo, K. Huang, F. Ji, W. Wu and H. Jiang, Chem. Commun., 2015, 51, 8857
DOI: 10.1039/C5CC02110C

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