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Issue 37, 2015
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Pd-catalyzed carbonylative access to aroyl phosphonates from (hetero)aryl bromides

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Abstract

The first transition-metal catalysed carbonylation with a phosphorus nucleophile is presented. This transformation provides efficient and mild access to aroylphosphonates under mild conditions, thus ensuring a broad substrate scope. The utility of aroylphosphonates as useful reagents, capable of participating in a number of transformations, is subsequently demonstrated. Furthermore, access to [13C]-carbonyl labelled aroylphosphonates is easily realised for the first time, as only a near stoichiometric amount of CO is required applying this carbonylation.

Graphical abstract: Pd-catalyzed carbonylative access to aroyl phosphonates from (hetero)aryl bromides

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Article information


Submitted
11 Mar 2015
Accepted
01 Apr 2015
First published
01 Apr 2015

Chem. Commun., 2015,51, 7831-7834
Article type
Communication
Author version available

Pd-catalyzed carbonylative access to aroyl phosphonates from (hetero)aryl bromides

Z. Lian, H. Yin, S. D. Friis and T. Skrydstrup, Chem. Commun., 2015, 51, 7831
DOI: 10.1039/C5CC02085A

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