Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation

Jiaxi Li; Chengye Si; Hongcheng Sun; Junyan Zhu; Tiezheng Pan; Shengda Liu; Zeyuan Dong; Jiayun Xu; Quan Luo; Junqiu Liu

doi:10.1039/C5CC02038G

Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation†

Jiaxi Li,^a Chengye Si,^a Hongcheng Sun,^a Junyan Zhu,^a Tiezheng Pan,^a Shengda Liu,^a Zeyuan Dong,^a Jiayun Xu,^a Quan Luo^a and Junqiu Liu*^a

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^a Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, People's Republic of China
E-mail: junqiuliu@jlu.edu.cn

Abstract

A pH-responsive artificial selenoenzyme was constructed by reversible binding between organoselenium compound 1 and CB[6] to form a pseudorotaxane-based molecular switch in response to pH stimuli. The glutathione peroxidase (GPx) activity of the artificial selenoenzyme can be switched on/off in a mild and body suitable environment between pH = 7 and pH = 6.

Chemical Communications

Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation†

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Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation

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