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Issue 38, 2015
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Saccharothriolides A–C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

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Abstract

Three new 10-membered macrolides, saccharothriolides A–C (1–3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

Graphical abstract: Saccharothriolides A–C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

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Supplementary files

Article information


Submitted
08 Mar 2015
Accepted
31 Mar 2015
First published
01 Apr 2015

This article is Open Access

Chem. Commun., 2015,51, 8074-8077
Article type
Communication

Saccharothriolides A–C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

S. Lu, S. Nishimura, G. Hirai, M. Ito, T. Kawahara, M. Izumikawa, M. Sodeoka, K. Shin-ya, T. Tsuchida and H. Kakeya, Chem. Commun., 2015, 51, 8074
DOI: 10.1039/C5CC01953B

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