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Issue 48, 2015
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Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application

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Abstract

The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.

Graphical abstract: Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application

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Publication details

The article was received on 05 Mar 2015, accepted on 13 May 2015 and first published on 13 May 2015


Article type: Communication
DOI: 10.1039/C5CC01896J
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Chem. Commun., 2015,51, 9857-9859

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    Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application

    R. E. Mewis, M. Fekete, G. G. R. Green, A. C. Whitwood and S. B. Duckett, Chem. Commun., 2015, 51, 9857
    DOI: 10.1039/C5CC01896J

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