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Issue 38, 2015
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Inhibited fragmentation of mAbs in buffered ionic liquids

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Abstract

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

Graphical abstract: Inhibited fragmentation of mAbs in buffered ionic liquids

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Publication details

The article was received on 05 Mar 2015, accepted on 02 Apr 2015 and first published on 02 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC01877C
Chem. Commun., 2015,51, 8089-8092

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    Inhibited fragmentation of mAbs in buffered ionic liquids

    R. R. Mazid, R. Vijayaraghavan, D. R. MacFarlane, C. Cortez-Jugo and W. Cheng, Chem. Commun., 2015, 51, 8089
    DOI: 10.1039/C5CC01877C

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