Issue 40, 2015

Influence of key amino acid mutation on the active site structure and on folding in acetyl-CoA synthase: a theoretical perspective

Abstract

Ad hoc quantum chemical modeling of the acetyl-CoA synthase local structure and folding allowed us to identify an unprecedented coordination mode of histidine sidechain to protein-embedded metal ions.

Graphical abstract: Influence of key amino acid mutation on the active site structure and on folding in acetyl-CoA synthase: a theoretical perspective

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2015
Accepted
07 Apr 2015
First published
07 Apr 2015

Chem. Commun., 2015,51, 8551-8554

Author version available

Influence of key amino acid mutation on the active site structure and on folding in acetyl-CoA synthase: a theoretical perspective

C. Greco, A. Ciancetta, M. Bruschi, A. Kulesza, G. Moro and U. Cosentino, Chem. Commun., 2015, 51, 8551 DOI: 10.1039/C5CC01575H

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