Jump to main content
Jump to site search

Issue 35, 2015
Previous Article Next Article

A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

Author affiliations

Abstract

A catalytic two-step reaction sequence was developed to access a range of complex heterocyclic frameworks based on biorelevant indole/oxindole scaffolds. The reaction sequence includes catalytic Pictet–Spengler cyclization followed by Au(I) catalyzed intramolecular hydroamination of acetylenes. A related cascade polycyclization of a designed β-carboline embodying a 1,5-enyne group yields the analogues of the alkaloid harmicine.

Graphical abstract: A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

Back to tab navigation

Supplementary files

Article information


Submitted
20 Feb 2015
Accepted
20 Mar 2015
First published
20 Mar 2015

Chem. Commun., 2015,51, 7536-7539
Article type
Communication
Author version available

A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

A. Danda, K. Kumar and H. Waldmann, Chem. Commun., 2015, 51, 7536
DOI: 10.1039/C5CC01555C

Social activity

Search articles by author

Spotlight

Advertisements