Issue 27, 2015

A protease inhibition strategy based on acceleration of autolysis

Abstract

We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.

Graphical abstract: A protease inhibition strategy based on acceleration of autolysis

Supplementary files

Article information

Article type
Communication
Submitted
16 Feb 2015
Accepted
25 Feb 2015
First published
25 Feb 2015

Chem. Commun., 2015,51, 5959-5962

Author version available

A protease inhibition strategy based on acceleration of autolysis

Y. Lv, J. Zhang, H. Wu, S. Zhao, Y. Song, S. Wang, B. Wang, G. Lv and X. Ma, Chem. Commun., 2015, 51, 5959 DOI: 10.1039/C5CC01448D

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