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Issue 31, 2015
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Rh/Cu-catalyzed multiple C–H, C–C, and C–N bond cleavage: facile synthesis of pyrido[2,1-a]indoles from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols

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Abstract

An unusual Rh/Cu-catalyzed synthesis of pyrido[2,1-a]indoles starting from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols was presented. The multi-step cascade transformations formally involve the cleavage of two C–H, three C–C, and one C–N bonds with concomitant construction of two C–H, four C–C, and one C–N bonds with excellent chemoselectivity in one-pot reaction.

Graphical abstract: Rh/Cu-catalyzed multiple C–H, C–C, and C–N bond cleavage: facile synthesis of pyrido[2,1-a]indoles from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols

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Article information


Submitted
14 Feb 2015
Accepted
09 Mar 2015
First published
10 Mar 2015

This article is Open Access

Chem. Commun., 2015,51, 6777-6780
Article type
Communication
Author version available

Rh/Cu-catalyzed multiple C–H, C–C, and C–N bond cleavage: facile synthesis of pyrido[2,1-a]indoles from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols

T. Li, Z. Wang, M. Zhang, H. Zhang and T. Wen, Chem. Commun., 2015, 51, 6777
DOI: 10.1039/C5CC01412C

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