Cu-catalyzed selective cascade sp3 C–H bond oxidative functionalization towards isoxazoline derivatives

Abstract

The first Cu-catalyzed cascade sp³ C–H bond oxidative functionalization of the 2-ethylazaarenes has been developed. The two different sp³ C–H bonds in 2-ethylazaarenes are selectively oxidized and four new types of bonds (CO, CN, C–C, C–O) are constructed in one operation. Starting from the simple substrates and cheap nitro source, this reaction provides an efficient approach to produce new kinds of isoxazolines.