Issue 27, 2015
From the journal:

Chemical Communications

Introducing a new radical trifluoromethylation reagent†‡

Azusa Sato,a   Jianlin Han,b   Taizo Ono,c   Alicja Wzorek,d   José Luis Aceñae  and  Vadim A. Soloshonok*ef  

* Corresponding authors

a Department of Chemistry, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666 Tokyo, Japan

b School of Chemistry and Chemical Engineering, Nanjing University, 210093 Nanjing, China

c National Institute of Advanced Industrial Science and Technology (AIST), 2266-98 Anagahora, Shimoshidami, Moriyama, Nagoya, Aichi, Japan

d Institute of Chemistry, Jan Kochanowski University in Kielce, Świętokrzyska 15G, 25-406 Kielce, Poland

e Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain
E-mail: vadym.soloshonok@ehu.es
Fax: +34-943-015270
Tel: +34-943-015177

f IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain

Abstract

Perfluoro-3-ethyl-2,4-dimethyl-3-pentyl radical (PPFR) is a persistent radical stable at room temperature, but easily decomposes at 90 °C to produce a CF3 radical which is able to react with a variety of aromatic compounds to afford the corresponding trifluoromethyl derivatives, usually as mixtures of regioisomers in good to excellent overall yields.

Graphical abstract: Introducing a new radical trifluoromethylation reagent

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC00905G
Article type
Communication
Submitted
30 Jan 2015
Accepted
24 Feb 2015
First published
24 Feb 2015

Chem. Commun., 2015,51, 5967-5970

Permissions

Request permissions

Introducing a new radical trifluoromethylation reagent

A. Sato, J. Han, T. Ono, A. Wzorek, J. L. Aceña and V. A. Soloshonok, Chem. Commun., 2015, 51, 5967 DOI: 10.1039/C5CC00905G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements