Issue 23, 2015
From the journal:

Chemical Communications

Triple helix conformation-specific blinking of Cy3 in DNA†

Kiyohiko Kawai*ab  and  Atsushi Maruyamac  

* Corresponding authors

a The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 5670047, Japan
E-mail: kiyohiko@sanken.osaka-u.ac.jp

b PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

c Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori-ku, Yokohama 226-8501, Japan

Abstract

We report that Cy3 undergoes triple helix conformation-specific blinking in DNA. Blinking patterns were affected by the stabilization of the Hoogsteen base-pair, suggesting that not only the presence but also the fluctuating behaviour of the triple helix can be monitored by the changes in the Cy3 blinking patterns.

Graphical abstract: Triple helix conformation-specific blinking of Cy3 in DNA

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Article information

DOI
https://doi.org/10.1039/C5CC00607D
Article type
Communication
Submitted
22 Jan 2015
Accepted
11 Feb 2015
First published
11 Feb 2015

Chem. Commun., 2015,51, 4861-4864

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Triple helix conformation-specific blinking of Cy3 in DNA

K. Kawai and A. Maruyama, Chem. Commun., 2015, 51, 4861 DOI: 10.1039/C5CC00607D

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