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Issue 41, 2015
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Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides

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Abstract

We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.

Graphical abstract: Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides

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Article information


Submitted
19 Jan 2015
Accepted
08 Apr 2015
First published
14 Apr 2015

Chem. Commun., 2015,51, 8652-8655
Article type
Communication

Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides

R. He, Y. Huang, C. Chiang, Y. Tsai, T. Ye, H. Gao, C. Wu, H. Lee and J. J. Huang, Chem. Commun., 2015, 51, 8652
DOI: 10.1039/C5CC00513B

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