Issue 26, 2015
From the journal:

Chemical Communications

Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan†

T. Ramasamy,a   H. B. Ruttala,a   J. Y. Choi,a   T. H. Tran,a   J. H. Kim,a   S. K. Ku,b   H. G. Choi,c   C. S. Yong*a  and  J. O. Kim*a  

* Corresponding authors

a College of Pharmacy, Yeungnam University, 214-1, Dae-dong, Gyeongsan, South Korea
E-mail: csyong@ynu.ac.kr, jongohkim@yu.ac.kr

b College of Korean Medicine, Daegu Haany University, Gyeongsan, South Korea

c College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, 55, Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, South Korea

Abstract

We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer. It shows great potential for the treatment of a broad range of cancers.

Graphical abstract: Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan

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Article information

DOI
https://doi.org/10.1039/C5CC00482A
Article type
Communication
Submitted
17 Jan 2015
Accepted
18 Feb 2015
First published
19 Feb 2015

Chem. Commun., 2015,51, 5758-5761

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Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan

T. Ramasamy, H. B. Ruttala, J. Y. Choi, T. H. Tran, J. H. Kim, S. K. Ku, H. G. Choi, C. S. Yong and J. O. Kim, Chem. Commun., 2015, 51, 5758 DOI: 10.1039/C5CC00482A

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