Issue 26, 2015

Mode of iron(iii) chelation by hexadentate hydroxypyridinones

Abstract

Tripodal hexadentate hydroxypyridin-4-ones are increasingly utilised as iron(III) and gallium(III) ligands, their attachment to proteins being particularly useful for positron emission tomography (PET). A widely studied tripodal ligand NTA(BuHP)3, which is reported to form 1 : 1 iron(III) and gallium(III) complexes in aqueous, media forms 2 : 2 complexes under physiological conditions. This important difference has implications for both iron chelation therapy and PET imaging.

Graphical abstract: Mode of iron(iii) chelation by hexadentate hydroxypyridinones

Supplementary files

Article information

Article type
Communication
Submitted
26 Dec 2014
Accepted
16 Jan 2015
First published
16 Jan 2015

Chem. Commun., 2015,51, 5614-5617

Mode of iron(III) chelation by hexadentate hydroxypyridinones

T. Zhou, R. C. Hider and X. Kong, Chem. Commun., 2015, 51, 5614 DOI: 10.1039/C4CC10339D

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