Issue 19, 2015
From the journal:

Chemical Communications

An artificial CO-releasing metalloprotein built by histidine-selective metallation†

Inês S. Albuquerque,a   Hélia F. Jeremias,b   Miguel Chaves-Ferreira,a   Dijana Matak-Vinkovic,c   Omar Boutureira,c   Carlos C. Romãob  and  Gonçalo J. L. Bernardes*ac  

* Corresponding authors

a Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal
E-mail: gbernardes@medicina.ulisboa.pt

b Instituto de Tecnologia Química e Biológica-António Xavier, Universidade Nova de Lisboa, Av da República, 2780-157 Oeiras, Portugal

c Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK
E-mail: gb453@cam.ac.uk
Web: http://gbernardes-lab.com

Abstract

We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4]2+ reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-RuII(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells.

Graphical abstract: An artificial CO-releasing metalloprotein built by histidine-selective metallation

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Article information

DOI
https://doi.org/10.1039/C4CC10204E
Article type
Communication
Submitted
21 Dec 2014
Accepted
30 Jan 2015
First published
30 Jan 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 3993-3996

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An artificial CO-releasing metalloprotein built by histidine-selective metallation

I. S. Albuquerque, H. F. Jeremias, M. Chaves-Ferreira, D. Matak-Vinkovic, O. Boutureira, C. C. Romão and G. J. L. Bernardes, Chem. Commun., 2015, 51, 3993 DOI: 10.1039/C4CC10204E

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