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Issue 23, 2015
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Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging

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Abstract

Superpositively charged mutants of green fluorescent protein (GFP) demonstrated a dramatically improved chemical exchange saturation transfer (CEST) MRI contrast compared to their wild type counterparts. The mutants +36 GFP and +48 GFP were successfully expressed in mammalian cells and retained part of their fluorescence, making them a new potential bimodal reporter gene.

Graphical abstract: Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging

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Supplementary files

Article information


Submitted
21 Dec 2014
Accepted
13 Feb 2015
First published
13 Feb 2015

Chem. Commun., 2015,51, 4869-4871
Article type
Communication
Author version available

Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging

A. Bar-Shir, Y. Liang, K. W. Y. Chan, A. A. Gilad and J. W. M. Bulte, Chem. Commun., 2015, 51, 4869
DOI: 10.1039/C4CC10195B

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