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Issue 16, 2015
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Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes: facile access to β-fluoro-N-protected phenethylamines

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Abstract

A copper-catalyzed regio- and intermolecular aminofluorination of styrenes has been developed. In this reaction Ph-I[double bond, length as m-dash]N-Ts and Et3N·3HF act as nitrogen and fluorine sources, respectively. The obtained β-fluoro-N-Ts-phenethylamines can be N-alkylated with subsequent deprotection affording the corresponding β-fluoro-N-alkylated phenethylamines, which are interesting building blocks for compounds acting on neuronal targets.

Graphical abstract: Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes: facile access to β-fluoro-N-protected phenethylamines

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Publication details

The article was received on 19 Dec 2014, accepted on 14 Jan 2015 and first published on 15 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC10162F
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Chem. Commun., 2015,51, 3379-3382

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    Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes: facile access to β-fluoro-N-protected phenethylamines

    J. Saavedra-Olavarría, G. C. Arteaga, J. J. López and E. G. Pérez, Chem. Commun., 2015, 51, 3379
    DOI: 10.1039/C4CC10162F

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