Issue 22, 2015
From the journal:

Chemical Communications

A smart DNA–gold nanoparticle probe for detecting single-base changes on the platform of a quartz crystal microbalance†

Hui Li,ab   Shiyan Xiao,a   Dongbao Yao,a   Michael Hon-Wah Lam*b  and  Haojun Liang*ac  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: hjliang@ustc.edu.cn

b Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
E-mail: bhmhwlam@cityu.edu.hk

c Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, and Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China, Hefei, Anhui 230026, China

Abstract

A design of DNA–gold nanoparticle probe-fueled DNA strand displacements for detecting single-base changes on the platform of a quartz crystal microbalance with random sequences was developed. After optimizing and testing the detection system, it has been successfully applied to detect mutation of a realistic sequence associated with human cancer, thereby indicating that this method has potential applicability in general.

Graphical abstract: A smart DNA–gold nanoparticle probe for detecting single-base changes on the platform of a quartz crystal microbalance

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Article information

DOI
https://doi.org/10.1039/C4CC10114F
Article type
Communication
Submitted
18 Dec 2014
Accepted
09 Feb 2015
First published
10 Feb 2015

Chem. Commun., 2015,51, 4670-4673

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A smart DNA–gold nanoparticle probe for detecting single-base changes on the platform of a quartz crystal microbalance

H. Li, S. Xiao, D. Yao, M. H. Lam and H. Liang, Chem. Commun., 2015, 51, 4670 DOI: 10.1039/C4CC10114F

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