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Issue 18, 2015
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A survey of advancements in nucleic acid-based logic gates and computing for applications in biotechnology and biomedicine

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Abstract

Nucleic acid-based logic devices were first introduced in 1994. Since then, science has seen the emergence of new logic systems for mimicking mathematical functions, diagnosing disease and even imitating biological systems. The unique features of nucleic acids, such as facile and high-throughput synthesis, Watson–Crick complementary base pairing, and predictable structures, together with the aid of programming design, have led to the widespread applications of nucleic acids (NA) for logic gate and computing in biotechnology and biomedicine. In this feature article, the development of in vitro NA logic systems will be discussed, as well as the expansion of such systems using various input molecules for potential cellular, or even in vivo, applications.

Graphical abstract: A survey of advancements in nucleic acid-based logic gates and computing for applications in biotechnology and biomedicine

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Publication details

The article was received on 16 Dec 2014, accepted on 09 Jan 2015 and first published on 09 Jan 2015


Article type: Feature Article
DOI: 10.1039/C4CC10047F
Citation: Chem. Commun., 2015,51, 3723-3734

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    A survey of advancements in nucleic acid-based logic gates and computing for applications in biotechnology and biomedicine

    C. Wu, S. Wan, W. Hou, L. Zhang, J. Xu, C. Cui, Y. Wang, J. Hu and W. Tan, Chem. Commun., 2015, 51, 3723
    DOI: 10.1039/C4CC10047F

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