Issue 14, 2015
From the journal:

Chemical Communications

Single-base mismatch discrimination by T7 exonuclease with target cyclic amplification detection†

Zhen-Kun Wu,a   Dian-Ming Zhou,a   Zhan Wu,*a   Xia Chu,a   Ru-Qin Yua  and  Jian-Hui Jiang*a  

* Corresponding authors

a State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China
E-mail: wuzhan1002@gmail.com, jianhuijiang@hnu.edu.cn
Fax: +86-731-88821848
Tel: +86-731-88664085

Abstract

T7 exonuclease is reported for the first time to have high specificity in discriminating single-base mismatch and utilized for developing a target cyclic amplification biosensor strategy for sensitive SNP detection based on graphene oxide quenching of uncleaved probes.

Graphical abstract: Single-base mismatch discrimination by T7 exonuclease with target cyclic amplification detection

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Article information

DOI
https://doi.org/10.1039/C4CC09984B
Article type
Communication
Submitted
15 Dec 2014
Accepted
09 Jan 2015
First published
09 Jan 2015

Chem. Commun., 2015,51, 2954-2956

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Single-base mismatch discrimination by T7 exonuclease with target cyclic amplification detection

Z. Wu, D. Zhou, Z. Wu, X. Chu, R. Yu and J. Jiang, Chem. Commun., 2015, 51, 2954 DOI: 10.1039/C4CC09984B

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